Selective Orthosteric Free Fatty Acid Receptor 2 (FFA2) Agonists

Free fatty acid receptor 2 (FFA2; GPR43) is a G protein-coupled seven-transmembrane receptor for short-chain fatty acids (SCFAs) that is implicated in inflammatory and metabolic disorders. The SCFA propionate has close to optimal ligand efficiency for FFA2 and can hence be considered as highly poten...

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Veröffentlicht in:	The Journal of biological chemistry 2011-03, Vol.286 (12), p.10628-10640
Hauptverfasser:	Schmidt, Johannes, Smith, Nicola J., Christiansen, Elisabeth, Tikhonova, Irina G., Grundmann, Manuel, Hudson, Brian D., Ward, Richard J., Drewke, Christel, Milligan, Graeme, Kostenis, Evi, Ulven, Trond
Format:	Artikel
Sprache:	eng
Schlagworte:	7-Helix Receptor Drug Design Fatty Acid FFA2 FFA3 FFAR2 G Protein-coupled Receptors (GPCR) GPR41 GPR43 Signal Transduction
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