Cancer-associated p53 Tetramerization Domain Mutants

The tumor suppressor p53, a 393-amino acid transcription factor, induces cell cycle arrest and apoptosis in response to genotoxic stress. Its inactivation via the mutation of its gene is a key step in tumor progression, and tetramer formation is critical for p53 post-translational modification and i...

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Veröffentlicht in:	The Journal of biological chemistry 2011-01, Vol.286 (1), p.252-258
Hauptverfasser:	Kamada, Rui, Nomura, Takao, Anderson, Carl W., Sakaguchi, Kazuyasu
Format:	Artikel
Sprache:	eng
Schlagworte:	Mutant p53 Protein Oligomerization Protein Stability Thermal Denaturation Thermodynamics Tumor Suppressor
Online-Zugang:	Volltext
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