Non-core Region Modulates Interleukin-11 Signaling Activity

Human interleukin-11 (hIL-11) is a pleiotropic cytokine administered to patients with low platelet counts. From a structural point of view hIL-11 belongs to the long-helix cytokine superfamily, which is characterized by a conserved core motif consisting of four α-helices. We have investigated the re...

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Veröffentlicht in:	The Journal of biological chemistry 2011-03, Vol.286 (10), p.8085-8093
Hauptverfasser:	Yanaka, Saeko, 谷, 中冴子, Sano, Emiko, 佐, 野恵海子, Naruse, Norio, 成, 瀬紀男, Miura, Kin-ichiro, 三, 浦謹一郎, Futatsumori-Sugai, Mutsumi, 二, ツ森ー菅井睦美, Caaveiro, Jose M.M., Tsumoto, Kouhei, 津, 本浩平
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonist Antagonist Calorimetry Glycosylation Interleukin Protein Stability Surface Plasmon Resonance (SPR)
Online-Zugang:	Volltext
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