Involvement of the Mitochondrial Death Pathway in Chemopreventive Benzyl Isothiocyanate-induced Apoptosis

In the present study, we studied the molecular mechanism underlying cell death induced by a cancer chemoprotective compound benzyl isothiocyanate (BITC). The cytotoxic effect of BITC was examined in rat liver epithelial RL34 cells. Apoptosis was induced when the cells were treated with 20 μm BITC, c...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2002-03, Vol.277 (10), p.8492-8499
Hauptverfasser:	Nakamura, Yoshimasa, Kawakami, Makiko, Yoshihiro, Akira, Miyoshi, Noriyuki, Ohigashi, Hajime, Kawai, Kiyoshi, Osawa, Toshihiko, Uchida, Koji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticarcinogenic Agents - pharmacology Apoptosis Caspase 3 Caspases - metabolism Cell Death - drug effects Cell Line Cell Membrane - metabolism Cells, Cultured Cytochrome c Group - metabolism Dose-Response Relationship, Drug Enzyme Activation Epithelial Cells - drug effects Flow Cytometry Isothiocyanates - pharmacology Liver - cytology Liver - drug effects Membrane Potentials Mitochondria - metabolism Mitochondria - pathology Necrosis Oxidation-Reduction Phosphatidylserines - metabolism Rats Reactive Oxygen Species - metabolism Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!