DEF-1/ASAP1 Is a GTPase-activating Protein (GAP) for ARF1 That Enhances Cell Motility through a GAP-dependent Mechanism

DEF-1/ASAP1 is an ADP-ribosylation factor GTPase-activating protein (ARF GAP) that localizes to focal adhesions and is involved in cytoskeletal regulation. In this paper, we use a cell-based ARF GAP assay to demonstrate that DEF-1 functions as a GAP for ARF1 and not ARF6 in vivo. This degree of subs...

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Veröffentlicht in:	The Journal of biological chemistry 2002-03, Vol.277 (10), p.7962-7969
Hauptverfasser:	Furman, Craig, Short, Sarah M., Subramanian, Romesh R., Zetter, Bruce R., Roberts, Thomas M.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Adaptor Proteins, Signal Transducing ADP-Ribosylation Factor 1 - metabolism ADP-Ribosylation Factors - metabolism Animals Blotting, Western Carrier Proteins - metabolism Carrier Proteins - physiology Cell Line Cell Movement Cell Separation COS Cells Cytoskeletal Proteins - biosynthesis Cytoskeleton - metabolism DNA, Complementary - metabolism Dose-Response Relationship, Drug Glutathione Transferase - metabolism GTPase-Activating Proteins - chemistry GTPase-Activating Proteins - metabolism Humans Mice Microscopy, Fluorescence Paxillin Phosphoproteins - biosynthesis Platelet-Derived Growth Factor - metabolism Protein Binding Protein Structure, Tertiary Recombinant Fusion Proteins - metabolism Retroviridae - metabolism src Homology Domains Time Factors Transfection Zinc Fingers
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