A Partially Structured Species of β2-Microglobulin Is Significantly Populated under Physiological Conditions and Involved in Fibrillogenesis

The folding of β2-microglobulin (β2-m), the protein forming amyloid deposits in dialysis-related amyloidosis, involves formation of a partially folded conformation named I2, which slowly converts into the native fold, N. Here we show that the partially folded species I2 can be separated from N by ca...

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Veröffentlicht in:	The Journal of biological chemistry 2001-12, Vol.276 (50), p.46714-46721
Hauptverfasser:	Chiti, Fabrizio, De Lorenzi, Ersilia, Grossi, Silvia, Mangione, Palma, Giorgetti, Sofia, Caccialanza, Gabriele, Dobson, Christopher M., Merlini, Giampaolo, Ramponi, Giampietro, Bellotti, Vittorio
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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