Metabolism of Prostaglandin Glycerol Esters and Prostaglandin Ethanolamides in Vitro and in Vivo

Prostaglandin glycerol esters (PG-Gs) and prostaglandin ethanolamides (PG-EAs) are generated by the action of cyclooxygenase-2 on the endocannabinoids 2-arachidonylglycerol (2-AG) and arachidonylethanolamide, respectively. These novel eicosanoids may have unique pharmacological properties and/or ser...

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Veröffentlicht in:	The Journal of biological chemistry 2001-10, Vol.276 (40), p.36993-36998
Hauptverfasser:	Kozak, Kevin R., Crews, Brenda C., Ray, Jennifer L., Tai, Hsin-Hsiung, Morrow, Jason D., Marnett, Lawrence J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cannabinoid Receptor Modulators Dinoprostone - analogs & derivatives Dinoprostone - metabolism Dinoprostone - pharmacokinetics Drug Stability Esters - metabolism Ethanolamines - metabolism Ethanolamines - pharmacokinetics Glycerides - metabolism Glycerides - pharmacokinetics Humans Hydroxyprostaglandin Dehydrogenases - metabolism Male Plasma - metabolism Prostaglandins - metabolism Rats Rats, Sprague-Dawley
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