Properties and Regulation of Organic Cation Transport in Freshly Isolated Human Proximal Tubules

The kidney, and more specifically the proximal tubule, is the main site of elimination of cationic endogenous metabolites and xenobiotics. Although numerous studies exist on renal organic cation transport of rat and rabbit, no information is available from humans. Therefore, we examined organic cati...

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Veröffentlicht in:	The Journal of biological chemistry 2001-09, Vol.276 (36), p.33741-33746
Hauptverfasser:	Pietig, Gesine, Mehrens, Thomas, Hirsch, Jochen R., Çetinkaya, Ibrahim, Piechota, Hansjürgen, Schlatter, Eberhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Transport Cations Cell Membrane - metabolism Cloning, Molecular Cyclic AMP-Dependent Protein Kinases - metabolism Cyclic GMP - analogs & derivatives Cyclic GMP - metabolism Diglycerides - metabolism Dose-Response Relationship, Drug Fluorescent Dyes - pharmacology HeLa Cells Humans Kidney Tubules - metabolism Kinetics Potassium - pharmacology Protein Kinase C - metabolism Pyridinium Compounds - pharmacology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Spectrometry, Fluorescence
Online-Zugang:	Volltext
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