Stimulation of Lipolysis and Hormone-sensitive Lipase via the Extracellular Signal-regulated Kinase Pathway

Hormonally stimulated lipolysis occurs by activation of cyclic AMP-dependent protein kinase (PKA) which phosphorylates hormone-sensitive lipase (HSL) and increases adipocyte lipolysis. Evidence suggests that catecholamines not only can activate PKA, but also the mitogen-activated protein kinase path...

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Veröffentlicht in:	The Journal of biological chemistry 2001-11, Vol.276 (48), p.45456-45461
Hauptverfasser:	Greenberg, A S, Shen, W J, Muliro, K, Patel, S, Souza, S C, Roth, R A, Kraemer, F B
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Binding Sites Cell Differentiation CHO Cells Cricetinae Enzyme Activation Enzyme Inhibitors - pharmacology Flavonoids - pharmacology Immunoblotting Isoproterenol - pharmacology Lipolysis - physiology MAP Kinase Signaling System Mice Mitogen-Activated Protein Kinases - metabolism Mutagenesis, Site-Directed Phosphorylation Plasmids - metabolism Serine - chemistry Signal Transduction Sterol Esterase - metabolism Tamoxifen - pharmacology Time Factors Transfection
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