Nck and Phosphatidylinositol 4,5-Bisphosphate Synergistically Activate Actin Polymerization through the N-WASP-Arp2/3 Pathway

The Wiskott-Aldrich syndrome protein (WASP) and its relative neural WASP (N-WASP) regulate the nucleation of actin filaments through their interaction with the Arp2/3 complex and are regulated in turn by binding to GTP-bound Cdc42 and phosphatidylinositol 4,5-bisphosphate. The Nck Src homology (SH)...

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Veröffentlicht in:	The Journal of biological chemistry 2001-07, Vol.276 (28), p.26448-26452
Hauptverfasser:	Rohatgi, Rajat, Nollau, Peter, Ho, Hsin-Yi Henry, Kirschner, Marc W., Mayer, Bruce J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin-Related Protein 2 Actin-Related Protein 3 Actins - chemistry Actins - drug effects Actins - metabolism Adaptor Proteins, Signal Transducing Animals Cell Line Cytoskeletal Proteins Dimerization Drug Synergism Escherichia coli Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - metabolism Oncogene Proteins - chemistry Oncogene Proteins - metabolism Oncogene Proteins - pharmacology Phosphatidylinositol 4,5-Diphosphate - chemistry Phosphatidylinositol 4,5-Diphosphate - metabolism Phosphatidylinositol 4,5-Diphosphate - pharmacology Signal Transduction - drug effects Wiskott-Aldrich Syndrome Protein, Neuronal
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