Differential Involvement of the Hyaluronan (HA) Receptors CD44 and Receptor for HA-mediated Motility in Endothelial Cell Function and Angiogenesis

Hyaluronan (HA), an important glycosaminoglycan constituent of the extracellular matrix, has been implicated in angiogenesis. It appears to exert its biological effects through binding interactions with at least two cell surface receptors: CD44 and receptor for HA-mediated motility (RHAMM). Recent i...

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Veröffentlicht in:	The Journal of biological chemistry 2001-09, Vol.276 (39), p.36770-36778
Hauptverfasser:	Savani, Rashmin C., Cao, Gaoyuan, Pooler, Patricia M., Zaman, Aisha, Zhou, Zhao, DeLisser, Horace M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biotinylation Blotting, Western Cell Adhesion Cell Division Cell Movement Cell Nucleus - metabolism Cell Separation Cells, Cultured Collagen - metabolism Cytoplasm - metabolism Drug Combinations Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Extracellular Matrix - metabolism Extracellular Matrix Proteins - metabolism Fibroblast Growth Factor 2 - metabolism Flow Cytometry Humans Hyaluronan Receptors - metabolism Hyaluronic Acid - chemistry Laminin - metabolism Mice Mice, Inbred C57BL Microscopy, Confocal Microscopy, Fluorescence Neovascularization, Physiologic Proteoglycans - metabolism Umbilical Veins - metabolism
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