Combined Antisense and Pharmacological Approaches Implicate hTASK as an Airway O2 Sensing K+Channel

Neuroepithelial bodies act as airway oxygen sensors. The lung carcinoma line H146 is an established model for neuroepithelial body cells. Although O2 sensing in both cells is via NADPH oxidase H2O2/free radical production and acute hypoxia promotes K+ channel closure and cell depolarization, the ide...

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Veröffentlicht in:	The Journal of biological chemistry 2001-07, Vol.276 (28), p.26499-26508
Hauptverfasser:	Hartness, Matthew E., Lewis, Anthony, Searle, Gavin J., O'Kelly, Ita, Peers, Chris, Kemp, Paul J.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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