Tissue Inhibitor of Metalloproteinases-2 (TIMP-2) Suppresses TKR-Growth Factor Signaling Independent of Metalloproteinase Inhibition

The tissue inhibitors of metalloproteinases (TIMPs) block matrix metalloproteinase (MMP)-mediated increases in cell proliferation, migration, and invasion that are associated with extracellular matrix (ECM) turnover. Here we demonstrate a direct role for TIMP-2 in regulating tyrosine kinase-type gro...

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Veröffentlicht in:	The Journal of biological chemistry 2001-02, Vol.276 (5), p.3203-3214
Hauptverfasser:	Hoegy, Susan E., Oh, Hae-Ryong, Corcoran, Marta L., Stetler-Stevenson, William G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Adenylyl Cyclases - metabolism Cell Division - drug effects Cyclic AMP-Dependent Protein Kinases - metabolism Enzyme Activation Epidermal Growth Factor - metabolism ErbB Receptors - metabolism GRB2 Adaptor Protein Humans Matrix Metalloproteinase 1 - metabolism Matrix Metalloproteinase Inhibitors Phosphorylation Protein Phosphatase 1 Protein Tyrosine Phosphatases - metabolism Proteins - metabolism Receptor Protein-Tyrosine Kinases - antagonists & inhibitors Receptor Protein-Tyrosine Kinases - metabolism Signal Transduction - drug effects Signal Transduction - physiology Tissue Inhibitor of Metalloproteinase-2 - pharmacology Tumor Cells, Cultured
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