Proteasome Involvement in Agonist-induced Down-regulation of μ and δ Opioid Receptors

This study investigated the mechanism of agonist-induced opioid receptor down-regulation. Incubation of HEK 293 cells expressing FLAG-tagged δ and μ receptors with agonists caused a time-dependent decrease in opioid receptor levels assayed by immunoblotting. Pulse-chase experiments using [35S]methio...

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Veröffentlicht in:	The Journal of biological chemistry 2001-04, Vol.276 (15), p.12345-12355
Hauptverfasser:	Chaturvedi, Kirti, Bandari, Persis, Chinen, Norihiro, Howells, Richard D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Cysteine Endopeptidases - metabolism Down-Regulation Humans Kinetics Multienzyme Complexes - metabolism Phosphorylation Proteasome Endopeptidase Complex Receptors, Opioid, delta - agonists Receptors, Opioid, delta - metabolism Receptors, Opioid, mu - agonists Receptors, Opioid, mu - metabolism Ubiquitins - metabolism
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