ATP-dependent Activation of the Intermediate Conductance, Ca2+-activated K+ Channel, hIK1, Is Conferred by a C-terminal Domain

We previously demonstrated that hIK1 is activated directly by ATP in excised, inside-out patches in a protein kinase A inhibitor 5–24 dependent manner, suggesting a role for phosphorylation in the regulation of this Ca2+-dependent channel. However, mutation of the single consensus cAMP-dependent pro...

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Veröffentlicht in:The Journal of biological chemistry 2001-04, Vol.276 (14), p.10963-10970
Hauptverfasser: Gerlach, Aaron C., Syme, Colin A., Giltinan, LeeAnn, Adelman, John P., Devor, Daniel C.
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Sprache:eng
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