Common Requirements for Melanocortin-4 Receptor Selectivity of Structurally Unrelated Melanocortin Agonist and Endogenous Antagonist, Agouti Protein

The activity of melanocortin receptors (MCR) is regulated by melanocortin peptide agonists and by the endogenous antagonists, Agouti protein and AgRP (Agouti-related protein). To understand how the selectivity for these structurally unrelated agonists and antagonist is achieved, chimeric and mutants...

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Veröffentlicht in:	The Journal of biological chemistry 2001-01, Vol.276 (2), p.931-936
Hauptverfasser:	Oosterom, Julia, Garner, Keith M., den Dekker, Wijnand K., Nijenhuis, Wouter A.J., Gispen, Willem Hendrik, Burbach, J. Peter H., Barsh, Greg S., Adan, Roger A.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agouti Signaling Protein Agouti-Related Protein alpha-MSH - antagonists & inhibitors alpha-MSH - pharmacology alpha-MSH - physiology Amino Acid Sequence Amino Acid Substitution Animals Binding Sites Cell Line Humans Intercellular Signaling Peptides and Proteins Kinetics Melanocyte-Stimulating Hormones - antagonists & inhibitors Molecular Sequence Data Mutagenesis, Site-Directed Protein Structure, Secondary Proteins - physiology Rats Receptor, Melanocortin, Type 4 Receptors, Corticotropin - chemistry Receptors, Corticotropin - physiology Recombinant Fusion Proteins Recombinant Proteins - chemistry Recombinant Proteins - metabolism Substrate Specificity Transfection
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