Architecture of Ca2+ Channel Pore-lining Segments Revealed by Covalent Modification of Substituted Cysteines

The cysteine accessibility method was used to explore calcium channel pore topology. Cysteine mutations were introduced into the SS1-SS2 segments of Motifs I-IV of the human cardiac L-type calcium channel, expressed in Xenopusoocytes and the current block by methanethiosulfonate compounds was measur...

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Veröffentlicht in:	The Journal of biological chemistry 2000-11, Vol.275 (44), p.34493-34500
Hauptverfasser:	Koch, Sheryl E., Bodi, Ilona, Schwartz, Arnold, Varadi, Gyula
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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