Decreased Glucose Transporter Expression Triggers BAX-dependent Apoptosis in the Murine Blastocyst

We report that a decrease in facilitative glucose transporter (GLUT1) expression and reduced glucose transport trigger apoptosis in the murine blastocyst. Inhibition of GLUT1 expression either by high glucose conditions or with antisense oligodeoxynucleotides significantly lowers protein expression...

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Veröffentlicht in:	The Journal of biological chemistry 2000-12, Vol.275 (51), p.40252-40257
Hauptverfasser:	Chi, Maggie M-Y, Pingsterhaus, Joyce, Carayannopoulos, Mary, Moley, Kelle H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Apoptosis - physiology bcl-2-Associated X Protein Diabetes Mellitus, Experimental - prevention & control Female Fetal Diseases - prevention & control Gene Expression Regulation - drug effects Glucose Transporter Type 1 Mice Molecular Probes Monosaccharide Transport Proteins - genetics Monosaccharide Transport Proteins - metabolism Oligonucleotides, Antisense - pharmacology Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-bcl-2
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