Flux Control of Cytochrome c Oxidase in Human Skeletal Muscle

In the present work, by titrating cytochrome c oxidase (COX) with the specific inhibitor KCN, the flux control coefficient and the metabolic reserve capacity of COX have been determined in human saponin-permeabilized muscle fibers. In the presence of the substrates glutamate and malate, a 2.3 Â± 0.2...

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Veröffentlicht in:	The Journal of biological chemistry 2000-09, Vol.275 (36), p.27741-27745
Hauptverfasser:	Kunz, W S, Kudin, A, Vielhaber, S, Elger, C E, Attardi, G, Villani, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - metabolism Adult Blotting, Southern Cell Membrane Permeability DNA, Mitochondrial - genetics Electron Transport Complex IV - antagonists & inhibitors Electron Transport Complex IV - genetics Electron Transport Complex IV - metabolism Humans Kinetics Middle Aged Mitochondria, Muscle - enzymology Mitochondrial Myopathies - enzymology Muscle Fibers, Skeletal - enzymology Muscle Fibers, Skeletal - pathology Muscle, Skeletal - enzymology Muscle, Skeletal - pathology Ophthalmoplegia, Chronic Progressive External - enzymology Ophthalmoplegia, Chronic Progressive External - genetics Ophthalmoplegia, Chronic Progressive External - pathology Oxygen Consumption - drug effects Potassium Cyanide - pharmacology Sequence Deletion
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