Dissecting Sites Important for Complement Regulatory Activity in Membrane Cofactor Protein (MCP; CD46)

Membrane cofactor protein (MCP; CD46), a widely distributed regulator of complement activation, is a cofactor for the factor I-mediated degradation of C3b and C4b deposited on host cells. MCP possesses four extracellular, contiguous complement control protein modules (CCPs) important for this inhibi...

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Veröffentlicht in:	The Journal of biological chemistry 2000-12, Vol.275 (48), p.37692-37701
Hauptverfasser:	Liszewski, M. Kathryn, Leung, Marilyn, Cui, Wenying, Subramanian, V. Bala, Parkinson, John, Barlow, Paul N., Manchester, Marianne, Atkinson, John P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Monoclonal - immunology Antigens, CD - chemistry Antigens, CD - genetics Antigens, CD - immunology Antigens, CD - metabolism Binding Sites CHO Cells Cricetinae Epitope Mapping Humans Membrane Cofactor Protein Membrane Glycoproteins - chemistry Membrane Glycoproteins - genetics Membrane Glycoproteins - immunology Membrane Glycoproteins - metabolism Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed Peptide Fragments - chemistry Peptide Fragments - metabolism Protein Conformation
Online-Zugang:	Volltext
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