Functional and Structural Analysis of ClC-K Chloride Channels Involved in Renal Disease

ClC-K channels belong to the CLC family of chloride channels and are predominantly expressed in the kidney. Genetic evidence suggests their involvement in transepithelial transport of chloride in distal nephron segments; ClC-K1 gene deletion leads to nephrogenic diabetes insipidus in mice, and mutat...

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Veröffentlicht in:	The Journal of biological chemistry 2000-08, Vol.275 (32), p.24527-24533
Hauptverfasser:	Waldegger, Siegfried, Jentsch, Thomas J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Anion Transport Proteins Bartter Syndrome - genetics Chloride Channels - chemistry Chloride Channels - genetics Chloride Channels - physiology Gene Deletion Humans Kidney Diseases - genetics Membrane Potentials Membrane Proteins Mice Models, Molecular Oocytes - physiology Patch-Clamp Techniques Point Mutation Protein Conformation Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism Xenopus laevis Xenopus Proteins
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