Myeloperoxidase Is Involved in H2O2-induced Apoptosis of HL-60 Human Leukemia Cells

We examined the mechanism of H2O2-induced cytotoxicity and its relationship to oxidation in human leukemia cells. The HL-60 promyelocytic leukemia cell line was sensitive to H2O2, and at concentrations up to about 20–25 μm, the killing was mediated by apoptosis. There was limited evidence of lipid p...

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Veröffentlicht in:	The Journal of biological chemistry 2000-07, Vol.275 (29), p.22461-22469
Hauptverfasser:	Wagner, Brett A., Buettner, Garry R., Oberley, Larry W., Darby, Christine J., Burns, C.Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Enzyme Activation HL-60 Cells - metabolism HL-60 Cells - pathology Humans Hydrogen Peroxide - pharmacology K562 Cells Oxidants - pharmacology Peroxidase - metabolism
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