Expression of the High Molecular Weight Fibroblast Growth Factor-2 Isoform of 210 Amino Acids Is Associated with Modulation of Protein Kinases C δ and ε and ERK Activation

The high molecular weight (HMW) fibroblast growth factor (FGF)-2 isoform of 210 amino acids initiated at a CUG start codon possesses a nuclear localization sequence and is not secreted. In contrast, the low molecular weight (LMW) isoform of 155 amino acids initiated at the AUG start codon can be sec...

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Veröffentlicht in:	The Journal of biological chemistry 2001-01, Vol.276 (2), p.1545-1554
Hauptverfasser:	Gaubert, François, Escaffit, Fabrice, Bertrand, Claudine, Korc, Murray, Pradayrol, Lucien, Clemente, François, Estival, Agnès
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Doxycycline - pharmacology Enzyme Activation Fibroblast Growth Factor 2 - chemistry Fibroblast Growth Factor 2 - metabolism Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Gene Expression Regulation, Enzymologic - physiology Isoenzymes - genetics Isoenzymes - metabolism Kinetics Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - metabolism Molecular Weight Pancreas Phosphorylation Protein Isoforms - chemistry Protein Isoforms - metabolism Protein Kinase C - genetics Protein Kinase C - metabolism Protein Kinase C-delta Protein Kinase C-epsilon Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - physiology Receptor, Fibroblast Growth Factor, Type 1 Receptors, Fibroblast Growth Factor - genetics Receptors, Fibroblast Growth Factor - physiology RNA, Messenger - genetics Transcription, Genetic - physiology Transfection
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