Superoxide Production and Reactive Oxygen Species Signaling by Endothelial Nitric-oxide Synthase

Reactive oxygen species can function as intracellular messengers, but linking these signaling events with specific enzymes has been difficult. Purified endothelial nitric-oxide synthase (eNOS) can generate superoxide (O⨪2) under special conditions but is only known to participate in cell signaling t...

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Veröffentlicht in:	The Journal of biological chemistry 2000-06, Vol.275 (22), p.16899-16903
Hauptverfasser:	Wang, Weihan, Wang, Shuibang, Yan, Liang, Madara, Patricia, Del Pilar Cintron, Ana, Wesley, Robert A., Danner, Robert L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Glycine - chemistry Glycine - metabolism Humans NADP - metabolism Nitric Oxide - metabolism Nitric Oxide Synthase - chemistry Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type III Reactive Oxygen Species Sequence Deletion Signal Transduction Superoxides - metabolism Tumor Necrosis Factor-alpha - metabolism U937 Cells
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