Inhibitory PAS Domain Protein (IPAS) Is a Hypoxia-inducible Splicing Variant of the Hypoxia-inducible Factor-3α Locus

The inhibitory PAS (Per/Arnt/Sim) domain protein, IPAS, functions as a dominant negative regulator of hypoxia-inducible transcription factors (HIFs) by forming complexes with those proteins that fail to bind to hypoxia response elements of target genes. We have previously observed that IPAS is predo...

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Veröffentlicht in:	The Journal of biological chemistry 2002-09, Vol.277 (36), p.32405-32408
Hauptverfasser:	Makino, Yuichi, Kanopka, Arvydas, Wilson, William J., Tanaka, Hirotoshi, Poellinger, Lorenz
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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