The Temperature-Signaling Cascade in Sponges Involves a Heat-Gated Cation Channel, Abscisic Acid, and Cyclic ADP-Ribose

Sponges (phylum Porifera) are the phylogenetically oldest metazoan animals, their evolution dating back to 600 million years ago. Here we demonstrate that sponges express ADP-ribosyl cyclase activity, which converts NAD+into cyclic ADP-ribose, a potent and universal intracellular Ca2+mobilizer. In A...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2001-12, Vol.98 (26), p.14859-14864
Hauptverfasser:	Zocchi, Elena, Carpaneto, Armando, Cerrano, Carlo, Bavestrello, Giorgio, Giovine, Marco, Bruzzone, Santina, Guida, Lucrezia, Franco, Luisa, Usai, Cesare
Format:	Artikel
Sprache:	eng
Schlagworte:	Abscisic Acid - biosynthesis Abscisic Acid - physiology Acids Adenosine Diphosphate Ribose - physiology ADP-ribosyl Cyclase ADP-ribosyl Cyclase 1 Animals Antigens, CD Antigens, Differentiation - metabolism Aquatic life Axinella polypoides Biological Sciences Calcium Chromatography, High Pressure Liquid Cyclic AMP-Dependent Protein Kinases - metabolism Demospongiae Enzyme Activation Enzymes Fluorescence Heat Heat stress disorders Hot Temperature Ion Channel Gating Ion Channels - metabolism Ion Channels - physiology Marine NAD+ Nucleosidase - metabolism Phosphorylation Pipettes Porifera Porifera - enzymology Porifera - metabolism Proteins Signal Transduction Spectrometry, Fluorescence Sponges Syntactical consequents Temperature Thermoreceptors
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