Synapse-specific catecholaminergic modulation of neuronal glutamate release

Norepinephrine in vertebrates and its invertebrate analog, octopamine, regulate the activity of neural circuits. We find that, when hungry, larvae switch activity in type II octopaminergic motor neurons (MNs) to high-frequency bursts, which coincide with locomotion-driving bursts in type I glutamate...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2025-01, Vol.122 (1), p.e2420496121
Hauptverfasser:	Bakshinska, Dariya, Liu, William YuChen, Schultz, Ryan, Stowers, R Steven, Hoagland, Adam, Cypranowska, Caroline, Stanley, Cherise, Younger, Susan H, Newman, Zachary L, Isacoff, Ehud Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Drosophila - metabolism Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Glutamic Acid - metabolism Larva - metabolism Locomotion - drug effects Motor Neurons - metabolism Octopamine - metabolism Receptors, Biogenic Amine - genetics Receptors, Biogenic Amine - metabolism Synapses - metabolism Synaptic Transmission - physiology
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