Selective Blockade of T Lymphocyte K+Channels Ameliorates Experimental Autoimmune Encephalomyelitis, A Model for Multiple Sclerosis

Adoptive transfer experimental autoimmune encephalomyelitis (AT-EAE), a disease resembling multiple sclerosis, is induced in rats by myelin basic protein (MBP)-activated CD4+T lymphocytes. By patch-clamp analysis, encephalitogenic rat T cells stimulated repeatedly in vitro expressed a unique channel...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2001-11, Vol.98 (24), p.13942-13947
Hauptverfasser:	Beeton, Christine, Wulff, Heike, Barbaria, Jocelyne, Clot-Faybesse, Olivier, Pennington, Michael, Bernard, Dominique, Cahalan, Michael D., Chandy, K. George, Béraud, Evelyne
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive transfer Animals Biological Sciences Calcium Channel Blockers - administration & dosage Calcium Channel Blockers - pharmacokinetics Calcium Channel Blockers - pharmacology CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - metabolism Cell lines Cells, Cultured Channel blockers Cnidarian Venoms - administration & dosage Cnidarian Venoms - pharmacokinetics Cnidarian Venoms - pharmacology Disease Disease models Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental - metabolism Encephalomyelitis, Autoimmune, Experimental - prevention & control Female Guinea Pigs Inhibitory concentration 50 Intermediate-Conductance Calcium-Activated Potassium Channels Isotope Labeling Kv1.3 Potassium Channel Multiple sclerosis Multiple Sclerosis - metabolism Multiple Sclerosis - prevention & control Nervous system diseases Phenotype Phenotypes Potassium Channel Blockers - administration & dosage Potassium Channel Blockers - pharmacokinetics Potassium Channel Blockers - pharmacology Potassium Channels - metabolism Potassium Channels, Voltage-Gated Preventive medicine Proteins Pyrazoles - administration & dosage Pyrazoles - pharmacokinetics Pyrazoles - pharmacology Rats Rats, Inbred Lew Rodents T lymphocytes Thymidine - metabolism Tritium - metabolism
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