Presynaptic neurons self-tune by inversely coupling neurotransmitter release with the abundance of CaV2 voltage-gated Ca 2+ channels

The abundance of CaV2 voltage-gated calcium channels is linked to presynaptic homeostatic plasticity (PHP), a process that recalibrates synaptic strength to maintain the stability of neural circuits. However, the molecular and cellular mechanisms governing PHP and CaV2 channels are not completely un...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2024-08, Vol.121 (35), p.e2404969121
Hauptverfasser:	Xiong, Ame, Richmond, Janet E, Kim, Hongkyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Calcium Channels - genetics Calcium Channels - metabolism Calcium Channels, N-Type - genetics Calcium Channels, N-Type - metabolism Membrane Proteins Mutation Neuronal Plasticity Neurons - metabolism Neurotransmitter Agents - metabolism Presynaptic Terminals - metabolism Synaptic Transmission - physiology
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