Mbd4 Inactivation Increases C→T Transition Mutations and Promotes Gastrointestinal Tumor Formation

Mbd4 (methyl-CpG binding domain 4) is a novel mammalian repair enzyme that has been implicated biochemically in the repair of mismatched G-T residues at methylated CpG sites. In addition, the human protein has been shown to interact with the DNA mismatch repair protein MLH1. To clarify the role of M...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2002-11, Vol.99 (23), p.14937-14942
Hauptverfasser:	Wong, Edmund, Yang, Kan, Kuraguchi, Mari, Werling, Uwe, Avdievich, Elena, Fan, Kunhua, Fazzari, Melissa, Jin, Bo, Anthony M.C. Brown, Lipkin, Martin, Edelmann, Winfried
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Biological Sciences Cancer DNA Exons Genetic mutation Genomes Mice Phenotypes Spleen Tumors
Online-Zugang:	Volltext
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