Identification of a β-arrestin-biased negative allosteric modulator for the β 2 -adrenergic receptor

Catecholamine-stimulated β -adrenergic receptor (β AR) signaling via the canonical G -adenylyl cyclase-cAMP-PKA pathway regulates numerous physiological functions, including the therapeutic effects of exogenous β-agonists in the treatment of airway disease. β AR signaling is tightly regulated by GRK...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2023-08, Vol.120 (31), p.e2302668120
Hauptverfasser:	Ippolito, Michael, De Pascali, Francesco, Hopfinger, Nathan, Komolov, Konstantin E, Laurinavichyute, Daniela, Reddy, Poli Adi Narayana, Sakkal, Leon A, Rajkowski, Kyle Z, Nayak, Ajay P, Lee, Justin, Lee, Jordan, Cao, Gaoyuan, Donover, Preston S, Reichman, Melvin, An, Steven S, Salvino, Joseph M, Penn, Raymond B, Armen, Roger S, Scott, Charles P, Benovic, Jeffrey L
Format:	Artikel
Sprache:	eng
Schlagworte:	Arrestin - metabolism beta-Arrestin 1 - genetics beta-Arrestin 1 - metabolism beta-Arrestins - metabolism Receptors, Adrenergic - metabolism Receptors, Adrenergic, beta-2 - genetics Receptors, Adrenergic, beta-2 - metabolism Signal Transduction
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