Adenosine A 2A receptor blockade prevents cisplatin-induced impairments in neurogenesis and cognitive function

Chemotherapy-induced cognitive impairment (CICI) has emerged as a significant medical problem without therapeutic options. Using the platinum-based chemotherapy cisplatin to model CICI, we revealed robust elevations in the adenosine A receptor (A R) and its downstream effectors, cAMP and CREB, by ci...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2022-07, Vol.119 (28), p.e2206415119
Hauptverfasser:	Oliveros, Alfredo, Yoo, Ki Hyun, Rashid, Mohammad Abdur, Corujo-Ramirez, Ana, Hur, Benjamin, Sung, Jaeyun, Liu, Yuanhang, Hawse, John R, Choi, Doo-Sup, Boison, Detlev, Jang, Mi-Hyeon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine A2 Receptor Antagonists - therapeutic use Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Chemotherapy-Related Cognitive Impairment - prevention & control Cisplatin - adverse effects Cognition - drug effects Hippocampus - drug effects Hippocampus - physiopathology Mice Mice, Inbred C57BL Neural Stem Cells - drug effects Neural Stem Cells - physiology Neurogenesis - drug effects Purines - administration & dosage Purines - therapeutic use Receptor, Adenosine A2A - metabolism
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