Increased p53 Mutation Load in Nontumorous Human Liver of Wilson Disease and Hemochromatosis: Oxyradical Overload Diseases

Hemochromatosis and Wilson disease (WD), characterized by the excess hepatic deposition of iron and copper, respectively, produce oxidative stress and increase the risk of liver cancer. Because the frequency of p53 mutated alleles in nontumorous human tissue may be a biomarker of oxyradical damage a...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2000-11, Vol.97 (23), p.12770-12775
Hauptverfasser:	Hussain, S. Perwez, Raja, Kamran, Amstad, Paul A., Sawyer, Mark, Trudel, Laura J., Wogan, Gerald N., Hofseth, Lorne J., Shields, Peter G., Billiar, Timothy R., Trautwein, Christian, Hohler, Thomas, Galle, Peter R., Phillips, David H., Markin, Rodney, Marrogi, Aizen J., Harris, Curtis C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - pharmacology Alleles Animals Biological Sciences Cancer Carcinogens Cell Line Codons Copper Copper - metabolism Disease Free Radicals Genes, MHC Class I Genetic mutation Hemochromatosis Hemochromatosis - genetics Hemochromatosis - pathology Hemochromatosis Protein Hepatolenticular degeneration Hepatolenticular Degeneration - genetics Hepatolenticular Degeneration - pathology Histocompatibility Antigens Class I - genetics HLA Antigens - genetics Humans Iron Iron - metabolism Liver Liver - metabolism Liver - pathology Medical research Membrane Proteins Mutagenesis - drug effects Mutation Nitric Oxide Synthase - biosynthesis Nitric Oxide Synthase Type II Oxidative stress Rabbits Tissue samples Tumor Suppressor Protein p53 - genetics
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