Quinol-Based Cyclic Antioxidant Mechanism in Estrogen Neuroprotection

Substantial evidence now exists that intrinsic free-radical scavenging contributes to the receptor-independent neuroprotective effects of estrogens. This activity is inherently associated with the presence of a phenolic A-ring in the steroid. We report a previously unrecognized antioxidant cycle tha...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-09, Vol.100 (20), p.11741-11746
Hauptverfasser:	Prokai, Laszlo, Prokai-Tatrai, Katalin, Perjesi, Pal, Zharikova, Alevtina D., Perez, Evelyn J., Liu, Ran, Simpkins, James W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Antioxidants - pharmacology Biological Sciences Brain damage Brain Ischemia - prevention & control Chromatography, Liquid Cultured cells Enzymes Estrogens Estrogens - pharmacology Female Free Radical Scavengers - pharmacology Free radicals Hydroquinones Hydroquinones - pharmacology Hydroxyl Radical Mass Spectrometry Neurology Neuroprotective Agents - pharmacology Oxidation Oxidative Stress Prodrugs Proteins Rats Rats, Sprague-Dawley Reactive oxygen species Reperfusion
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!