Australian funnel-web spiders evolved human-lethal δ-hexatoxins for defense against vertebrate predators

Australian funnel-web spiders are infamous for causing human fatalities, which are induced by venom peptides known as δ-hexatoxins (δ-HXTXs). Humans and other primates did not feature in the prey or predator spectrum during evolution of these spiders, and consequently the primate lethality of δ-HXTX...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-10, Vol.117 (40), p.24920-24928
Hauptverfasser:	Herzig, Volker, Sunagar, Kartik, Wilson, David T. R., Pineda, Sandy S., Israel, Mathilde R., Dutertre, Sebastien, McFarland, Brianna Sollod, Undheim, Eivind A. B., Hodgson, Wayne C., Alewood, Paul F., Lewis, Richard J., Bosmans, Frank, Vetter, Irina, King, Glenn F., Fry, Bryan G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence - genetics Animal behavior Animals Atrax robustus Australia Biological Sciences Channels Chemical Sciences Conservation Conserved sequence Conserved Sequence - genetics Deactivation Ecological effects Ecology, environment Evolution Evolution, Molecular Female Humans Inactivation Lethal effects Lethality Life Sciences Male Mice Molecular evolution Neurotoxins - chemistry Neurotoxins - genetics Neurotoxins - metabolism Pain perception Peptides Peptides - genetics Phylogeny Polyamines - chemistry Polyamines - metabolism Predators Prey Primates Sexual Behavior, Animal - physiology Sodium channels (voltage-gated) Species Spider Venoms - genetics Spiders Spiders - genetics Spiders - pathogenicity Symbiosis Toxins Transcriptome - genetics Venom Vertebrates Vertebrates - genetics Vertebrates - physiology Webs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!