Visualization of the HIV-1 Env glycan shield across scales

The dense array of N-linked glycans on the HIV-1 envelope glycoprotein (Env), known as the “glycan shield,” is a key determinant of immunogenicity, yet intrinsic heterogeneity confounds typical structure–function analysis. Here, we present an integrated approach of single-particle electron cryomicro...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-11, Vol.117 (45), p.28014-28025
Hauptverfasser:	Berndsen, Zachary T., Chakraborty, Srirupa, Wang, Xiaoning, Cottrell, Christopher A., Torres, Jonathan L., Diedrich, Jolene K., López, Cesar A., Yates, John R., van Gils, Marit J., Paulson, James C., Gnanakaran, Sandrasegaram, Ward, Andrew B.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Antibodies, Neutralizing - immunology Antibody Formation Biological Sciences Biotechnology Buried structures Cell lines Computer applications Computer Simulation cryo-EM Cryoelectron Microscopy - methods Deglycosylation env Gene Products, Human Immunodeficiency Virus - chemistry env Gene Products, Human Immunodeficiency Virus - immunology Epitopes - chemistry Function analysis Glycan glycoprotein Glycoproteins Glycosylation Heterogeneity HIV HIV Antibodies - immunology HIV Envelope Protein gp120 - metabolism HIV Seropositivity HIV-1 HIV-1 - immunology HIV-1 - metabolism Human immunodeficiency virus Humans Immune Evasion - immunology Immunogenicity Mass spectrometry Mass Spectrometry - methods Mass spectroscopy Models, Molecular molecular modeling Multidisciplinary Sciences N-glycans Occupancy Peptide mapping Polysaccharides Polysaccharides - metabolism Science & Technology Science & Technology - Other Topics Structure-function relationships Trimers vaccine Vaccines
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