Kinetic analysis of amino acid radicals formed in H 2 O 2 -driven Cu I LPMO reoxidation implicates dominant homolytic reactivity

Lytic polysaccharide monooxygenases (LPMOs) have been proposed to react with both [Formula: see text] and [Formula: see text] as cosubstrates. In this study, the [Formula: see text] reaction with reduced LPMO9A (Cu - LPMO9A) is demonstrated to be 1,000-fold faster than the [Formula: see text] reacti...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-06, Vol.117 (22), p.11916-11922
Hauptverfasser:	Jones, Stephen M, Transue, Wesley J, Meier, Katlyn K, Kelemen, Bradley, Solomon, Edward I
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - metabolism Binding Sites Biofuels Electron Spin Resonance Spectroscopy - methods Hydrogen Peroxide - metabolism Hypocrea - metabolism Kinetics Magnetic Resonance Spectroscopy - methods Mixed Function Oxygenases - chemistry Mixed Function Oxygenases - metabolism Oxidation-Reduction Peroxides - metabolism Polysaccharides - metabolism Tryptophan - metabolism Tyrosine - metabolism
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