Acrosin is essential for sperm penetration through the zona pellucida in hamsters

During natural fertilization, mammalian spermatozoa must pass through the zona pellucida before reaching the plasma membrane of the oocyte. It is assumed that this step involves partial lysis of the zona by sperm acrosomal enzymes, but there has been no unequivocal evidence to support this view. Her...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-02, Vol.117 (5), p.2513-2518
Hauptverfasser:	Hirose, Michiko, Honda, Arata, Fulka, Helena, Tamura-Nakano, Miwa, Matoba, Shogo, Tomishima, Toshiko, Mochida, Keiji, Hasegawa, Ayumi, Nagashima, Kiyoshi, Inoue, Kimiko, Ohtsuka, Masato, Baba, Tadashi, Yanagimachi, Ryuzo, Ogura, Atsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrosin Biological Sciences CRISPR Fertility Gametocytes Genital tract Hamsters In vitro fertilization Lysis Multidisciplinary Sciences Mutants Oocytes Oviduct Penetration Science & Technology Science & Technology - Other Topics Serine Serine proteinase Sperm Spermatozoa Transfection Zona pellucida
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