A Nonsense Mutation in the Gene Encoding 2′-5′-Oligoadenylate Synthetase/L1 Isoform Is Associated with West Nile Virus Susceptibility in Laboratory Mice

A mouse model has been established to investigate the genetic determinism of host susceptibility to West Nile (WN) virus, a member of the genus flavivirus and family Flaviviridae. Whereas WN virus causes encephalitis and death in most laboratory inbred mouse strains after peripheral inoculation, mos...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2002-08, Vol.99 (17), p.11311-11316
Hauptverfasser:	Mashimo, Tomoji, Lucas, Marianne, Simon-Chazottes, Dominique, Frenkiel, Marie-Pascale, Montagutelli, Xavier, Ceccaldi, Pierre-Emmanuel, Deubel, Vincent, Guénet, Jean-Louis, Desprès, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	2',5'-Oligoadenylate Synthetase - genetics Animals Animals, Laboratory Antibodies Base Sequence Biological Sciences Codon, Nonsense - genetics Crosses, Genetic DNA Primers Exons Genetic loci Genetic Predisposition to Disease Human genetics Immunity, Innate - genetics Inbred strains Infections Isoenzymes - genetics Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred Strains Molecular Sequence Data Phenotypes Protein isoforms Sequence Alignment Sequence Homology, Nucleic Acid Virulence Viruses West Nile Fever - genetics West Nile virus - classification West Nile virus - pathogenicity
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