Genomewide Insertional Mutagenesis in Streptomyces coelicolor Reveals Additional Genes Involved in Morphological Differentiation

The filamentous soil bacterium Streptomyces coelicolor undergoes a complex cycle of morphological differentiation involving the formation of an aerial mycelium and the production of pigmented antibiotics. We have developed a procedure for generating insertional mutants of S. coelicolor based on in v...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2000-08, Vol.97 (17), p.9642-9647
Hauptverfasser:	Gehring, Amy M., Nodwell, Justin R., Beverley, Stephen M., Losick, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anti-Bacterial Agents - pharmacology Bacteria Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - physiology Base Sequence Biological Sciences Chromosomes Chromosomes, Bacterial - genetics DNA Transposable Elements - genetics Genes Genes, Bacterial - genetics Genetic mutation Genetic transposition Genome, Bacterial Hybridity Microbial Sensitivity Tests Microbiology Molecular Sequence Data Multigene Family - genetics Mutagenesis, Insertional - genetics Mutation Nebramycin - analogs & derivatives Nebramycin - pharmacology Open reading frames Phenotype Phenotypes Physical Chromosome Mapping Pigments Pigments, Biological - biosynthesis Plasmids Recombination, Genetic - genetics Sequence Alignment Spores, Bacterial - cytology Spores, Bacterial - genetics Spores, Bacterial - growth & development Streptomyces - drug effects Streptomyces - genetics Streptomyces - growth & development Streptomyces - metabolism Streptomyces coelicolor Transposons
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