Structure–function analysis of myomaker domains required for myoblast fusion

During skeletal muscle development, myoblasts fuse to form multinucleated myofibers. Myomaker [Transmembrane protein 8c (TMEM8c)] is a muscle-specific protein that is essential for myoblast fusion and sufficient to promote fusion of fibroblasts with muscle cells; however, the structure and biochemic...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-02, Vol.113 (8), p.2116-2121
Hauptverfasser:	Millay, Douglas P., Gamage, Dilani G., Quinn, Malgorzata E., Min, Yi-Li, Mitani, Yasuyuki, Bassel-Duby, Rhonda, Olson, Eric N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Cell Fusion Cell Line Cell Membrane - chemistry Cell Membrane - genetics Cell Membrane - metabolism Cells Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Transgenic Muscle Development - physiology Muscle Proteins - chemistry Muscle Proteins - genetics Muscle Proteins - metabolism Musculoskeletal system Mutagenesis Mutation Myoblasts, Skeletal - chemistry Myoblasts, Skeletal - cytology Myoblasts, Skeletal - metabolism Protein Structure, Tertiary Proteins Structure-Activity Relationship
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