Presynaptic serotonin 2A receptors modulate thalamocortical plasticity and associative learning

Higher-level cognitive processes strongly depend on a complex interplay between mediodorsal thalamus nuclei and the prefrontal cortex (PFC). Alteration of thalamofrontal connectivity has been involved in cognitive deficits of schizophrenia. Prefrontal serotonin (5-HT)2A receptors play an essential r...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-03, Vol.113 (10), p.E1382-E1391
Hauptverfasser:	Barre, Alexander, Berthoux, Coralie, De Bundel, Dimitri, Valjent, Emmanuel, Bockaert, Joël, Marin, Philippe, Bécamel, Carine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal cognition Animals Association Learning - physiology Biological Sciences Blotting, Western Brain Cerebral Cortex - metabolism Cerebral Cortex - physiology Electrophysiological Phenomena Life Sciences Mice, Inbred C57BL Mice, Knockout Microscopy, Fluorescence Neurology Neuronal Plasticity - genetics Neuronal Plasticity - physiology Neuropsychology PNAS Plus Prefrontal Cortex - metabolism Prefrontal Cortex - physiology Protein Kinase C - metabolism Rats, Sprague-Dawley Receptor, Serotonin, 5-HT2A - genetics Receptor, Serotonin, 5-HT2A - metabolism Receptor, Serotonin, 5-HT2A - physiology Receptors, N-Methyl-D-Aspartate - metabolism Receptors, N-Methyl-D-Aspartate - physiology Rodents Schizophrenia Serotonin Synapses - metabolism Synapses - physiology Synaptic Transmission - genetics Synaptic Transmission - physiology Thalamus - metabolism Thalamus - physiology Type C Phospholipases - metabolism
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