Comparative systems pharmacology of HIF stabilization in the prevention of retinopathy of prematurity

Retinopathy of prematurity (ROP) causes 100,000 new cases of childhood blindness each year. ROP is initiated by oxygen supplementation necessary to prevent neonatal death. We used organ systems pharmacology to define the transcriptomes of mice that were cured of oxygen-induced retinopathy (OIR, ROP...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-05, Vol.113 (18), p.E2516-E2525
Hauptverfasser:	Hoppe, George, Yoon, Suzy, Gopalan, Banu, Savage, Alexandria R., Brown, Rebecca, Case, Kelsey, Vasanji, Amit, Chan, E. Ricky, Silver, Randi B., Sears, Jonathan E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Blindness Comparative analysis Dose-Response Relationship, Drug Gene expression Glycine - administration & dosage Glycine - analogs & derivatives Hypoxia-Inducible Factor 1 - antagonists & inhibitors Hypoxia-Inducible Factor 1 - metabolism Isoquinolines - administration & dosage Liver - drug effects Liver - metabolism Mice Mice, Inbred C57BL Pharmacology PNAS Plus Retina - drug effects Retina - metabolism Retinopathy of Prematurity - drug therapy Retinopathy of Prematurity - prevention & control Rodents Transcriptome - drug effects Treatment Outcome
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