Facultative cheating supports the coexistence of diverse quorum-sensing alleles
Bacterial quorum sensing enables bacteria to cooperate in a density-dependent manner via the group-wide secretion and detection of specific autoinducer molecules. Many bacterial species show high intraspecific diversity of autoinducer–receptor alleles, called pherotypes. The autoinducer produced by...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2016-02, Vol.113 (8), p.2152-2157 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Pollak, Shaul Omer-Bendori, Shira Even-Tov, Eran Lipsman, Valeria Bareia, Tasneem Ben-Zion, Ishay Eldar, Avigdor |
| description | Bacterial quorum sensing enables bacteria to cooperate in a density-dependent manner via the group-wide secretion and detection of specific autoinducer molecules. Many bacterial species show high intraspecific diversity of autoinducer–receptor alleles, called pherotypes. The autoinducer produced by one pherotype activates its coencoded receptor, but not the receptor of another pherotype. It is unclear what selection forces drive the maintenance of pherotype diversity. Here, we use the ComQXPA system of Bacillus subtilis as a model system, to show that pherotype diversity can be maintained by facultative cheating—a minority pherotype exploits the majority, but resumes cooperation when its frequency increases. We find that the maintenance of multiple pherotypes by facultative cheating can persist under kin-selection conditions that select against “obligate cheaters” quorum-sensing response null mutants. Our results therefore support a role for facultative cheating and kin selection in the evolution of quorum-sensing diversity. |
| doi_str_mv | 10.1073/pnas.1520615113 |
| format | Article |
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Many bacterial species show high intraspecific diversity of autoinducer–receptor alleles, called pherotypes. The autoinducer produced by one pherotype activates its coencoded receptor, but not the receptor of another pherotype. It is unclear what selection forces drive the maintenance of pherotype diversity. Here, we use the ComQXPA system of Bacillus subtilis as a model system, to show that pherotype diversity can be maintained by facultative cheating—a minority pherotype exploits the majority, but resumes cooperation when its frequency increases. We find that the maintenance of multiple pherotypes by facultative cheating can persist under kin-selection conditions that select against “obligate cheaters” quorum-sensing response null mutants. Our results therefore support a role for facultative cheating and kin selection in the evolution of quorum-sensing diversity.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.1520615113</identifier><identifier>PMID: 26787913</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Alleles ; Bacillus subtilis ; Bacillus subtilis - genetics ; Bacillus subtilis - physiology ; Bacteria ; Biodiversity ; Biological Evolution ; Biological Sciences ; Genes ; Genes, Bacterial ; Genetic Variation ; Models, Biological ; Models, Genetic ; Molecules ; Mutation ; Quorum Sensing - genetics ; Quorum Sensing - physiology</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2016-02, Vol.113 (8), p.2152-2157</ispartof><rights>Volumes 1–89 and 106–113, copyright as a collective work only; author(s) retains copyright to individual articles</rights><rights>Copyright National Academy of Sciences Feb 23, 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c565t-ed0e0eb1110bf7be532f6e128b7ae17e7cd5f1cdc0055a6bdde8fa8db30f0a293</citedby><cites>FETCH-LOGICAL-c565t-ed0e0eb1110bf7be532f6e128b7ae17e7cd5f1cdc0055a6bdde8fa8db30f0a293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/113/8.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/26467822$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/26467822$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27922,27923,53789,53791,58015,58248</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26787913$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pollak, Shaul</creatorcontrib><creatorcontrib>Omer-Bendori, Shira</creatorcontrib><creatorcontrib>Even-Tov, Eran</creatorcontrib><creatorcontrib>Lipsman, Valeria</creatorcontrib><creatorcontrib>Bareia, Tasneem</creatorcontrib><creatorcontrib>Ben-Zion, Ishay</creatorcontrib><creatorcontrib>Eldar, Avigdor</creatorcontrib><title>Facultative cheating supports the coexistence of diverse quorum-sensing alleles</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Bacterial quorum sensing enables bacteria to cooperate in a density-dependent manner via the group-wide secretion and detection of specific autoinducer molecules. 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| subjects | Alleles Bacillus subtilis Bacillus subtilis - genetics Bacillus subtilis - physiology Bacteria Biodiversity Biological Evolution Biological Sciences Genes Genes, Bacterial Genetic Variation Models, Biological Models, Genetic Molecules Mutation Quorum Sensing - genetics Quorum Sensing - physiology |
| title | Facultative cheating supports the coexistence of diverse quorum-sensing alleles |
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