Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: Insights from DNA complex structures

RecQ helicases are a widely conserved family of ATP-dependent motors with diverse roles in nearly every aspect of bacterial and eukaryotic genome maintenance. However, the physical mechanisms by which RecQ helicases recognize and process specific DNA replication and repair intermediates are largely...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-04, Vol.112 (14), p.4286-4291
Hauptverfasser:	Pike, Ashley C. W., Gomathinayagam, Shivasankari, Swuec, Paolo, Berti, Matteo, Zhang, Ying, Schnecke, Christina, Marino, Francesca, von Delft, Frank, Renault, Ludovic, Costa, Alessandro, Gileadi, Opher, Vindigni, Alessandro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Animals Binding sites Biological Sciences Cell adhesion & migration Chromatography, Gel Crystallization Crystallography, X-Ray Deoxyribonucleic acid DNA DNA - chemistry DNA Helicases - chemistry DNA, Cruciform - physiology DNA, Single-Stranded - chemistry Enzymes Escherichia coli - metabolism Humans Insecta Molecular Conformation Molecular structure Nucleic Acid Denaturation Nucleotides - chemistry Protein Binding Protein Structure, Tertiary RecQ Helicases - chemistry Zinc - chemistry
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