Intestinal myofibroblast-specific Tpl2-Cox-2-PGE 2 pathway links innate sensing to epithelial homeostasis

Tumor progression locus-2 (Tpl2) is a proinflammatory gene genetically associated with inflammatory bowel diseases. This study provides a mechanistic interpretation for this association showing a dominant Tpl2-mediated homeostatic mechanism protecting mice from epithelial injury-induced colitis. Thi...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-10, Vol.111 (43)
Hauptverfasser:	Roulis, Manolis, Nikolaou, Christoforos, Kotsaki, Elena, Kaffe, Eleanna, Karagianni, Niki, Koliaraki, Vasiliki, Salpea, Klelia, Ragoussis, Jiannis, Aidinis, Vassilis, Martini, Eva, Becker, Christoph, Herschman, Harvey R., Vetrano, Stefania, Danese, Silvio, Kollias, George
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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