XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313

X-linked inhibitor of apoptosis (XIAP)-associated factor 1 (XAF1) is a tumor suppressor that is frequently inactivated in many human cancers. However, the molecular mechanism underlying its growth-inhibitory function remains largely unknown. Here, we report that XAF1 forms a positive feedback loop w...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-10, Vol.111 (43), p.15532-15537
Hauptverfasser:	Lee, Min-Goo, Han, Jikhyon, Jeong, Seong-In, Her, Nam-Gu, Lee, Jin-Hee, Ha, Tae-Kyu, Kang, Min-Ju, Ryu, Byung-Kyu, Chi, Sung-Gil
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis Apoptosis - drug effects Biological Sciences Cancer Carrier Proteins - metabolism Cell cycle Cell lines Control loops Cyclin-Dependent Kinase Inhibitor p21 - metabolism Enzyme Activation - drug effects epigenetics Feedback, Physiological - drug effects Gene expression regulation HCT116 Cells Humans Intracellular Signaling Peptides and Proteins - chemistry Intracellular Signaling Peptides and Proteins - metabolism Mathematical functions Models, Biological Neoplasm Proteins - chemistry Neoplasm Proteins - metabolism Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Nuclear Proteins - metabolism Phosphorylation Phosphorylation - drug effects Phosphoserine - metabolism Protein Binding - drug effects Protein Isoforms - metabolism Protein Stability - drug effects Protein Structure, Tertiary Protein-Serine-Threonine Kinases - metabolism Proteins Proteolysis - drug effects Proto-Oncogene Proteins c-mdm2 - metabolism Remission Induction Signal Transduction - drug effects Tumor Suppressor Protein p53 - chemistry Tumor Suppressor Protein p53 - metabolism Tumors ubiquitin-protein ligase Ubiquitin-Protein Ligases - metabolism ubiquitination Ubiquitination - drug effects Ubiquitins zinc finger motif
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