Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice

Prolyl endopeptidase (PREP) has been implicated in neuronal functions. Here we report that hypothalamic PREP is predominantly expressed in the ventromedial nucleus (VMH), where it regulates glucose-induced neuronal activation. PREP knockdown mice (Prep ᵍᵗ/ᵍᵗ) exhibited glucose intolerance, decreased...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-08, Vol.111 (32), p.11876-11881
Hauptverfasser:	Kim, Jung Dae, Toda, Chitoku, D'Agostino, Giuseppe, Zeiss, Caroline J., DiLeone, Ralph J., Elsworth, John D., Kibbey, Richard G., Chan, Owen, Harvey, Brandon K., Richie, Christopher T., Savolainen, Mari, Myöhännen, Timo, Jeong, Jin Kwon, Diano, Sabrina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals autonomic nervous system Biological Sciences Blood Glucose - metabolism Brain Fasting Gene Expression Gene expression regulation Gene Knockdown Techniques Genotype & phenotype glucagon Glucagon - metabolism Glucose Glucose Clamp Technique Glucose Intolerance - enzymology Glucose Intolerance - etiology glucose tolerance Glucose tolerance test Hypothalamic regulation Hypothalamus Hypothalamus - enzymology Hypothalamus - physiology Indoles - pharmacology Insulin Insulin - metabolism Insulin Secretion Ion Channels - genetics islets of Langerhans Male mechanism of action Messenger RNA Mice Mice, Transgenic Mitochondrial Proteins - genetics Mode of action Nervous system norepinephrine Pancreas Pancreas - metabolism phenotype Phosphorylation propranolol Receptor, Insulin - metabolism Receptors Recombinant Proteins - genetics Recombinant Proteins - metabolism Rodents Serine Endopeptidases - deficiency Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Serine Proteinase Inhibitors - pharmacology Thiazolidines - pharmacology Uncoupling Protein 1 Ventromedial Hypothalamic Nucleus - enzymology Ventromedial Hypothalamic Nucleus - physiology
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