Lipid flippase modulates olfactory receptor expression and odorant sensitivity in Drosophila

In Drosophila melanogaster , the male-specific pheromone cVA (11- cis -vaccenyl acetate) functions as a sex-specific social cue. However, our understanding of the molecular mechanisms underlying cVA pheromone transduction and its regulation are incomplete. Using a genetic screen combined with an ele...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-05, Vol.111 (21), p.7831-7836
Hauptverfasser:	Ha, Tal Soo, Xia, Ruohan, Zhang, Haiying, Jin, Xin, Smith, Dean P.
Format:	Artikel
Sprache:	eng
Schlagworte:	acetates Adenosine triphosphatases adenosinetriphosphatase Animals Base Sequence Biological Sciences Cilia Complementary DNA dendrites DNA Primers - genetics Drosophila Drosophila melanogaster Drosophila melanogaster - physiology Drosophila Proteins - genetics Drosophila Proteins - metabolism electrophysiology Exons gene overexpression Genotypes Image Processing, Computer-Assisted Immunohistochemistry Insects Lipids loci mammals Molecular Sequence Data mutants Mutation Neurons odor compounds Oleic Acids - metabolism olfactory receptors Pheromones Pheromones - metabolism phosphatidylethanolamines phosphatidylserines Phospholipid Transfer Proteins - genetics Phospholipid Transfer Proteins - metabolism Proteins Receptors Receptors, Cell Surface - metabolism Receptors, Odorant - metabolism Reverse Transcriptase Polymerase Chain Reaction Sequence Analysis, DNA Smell - physiology transgenes Ungulates
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