Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign

HIV-1 neutralization requires Ab accessibility to the functional envelope glycoprotein (Env) spike. We recently reported the isolation of previously unidentified vaccine-elicited, CD4 binding site (CD4bs)-directed mAbs from rhesus macaques immunized with soluble Env trimers, indicating that this reg...

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Veröffentlicht in:	Proc. Natl. Acad. Sci. USA 2014-02, Vol.111 (7), p.E738-E747
Hauptverfasser:	Tran, Karen, Poulsen, Christian, Guenaga, Javier, de Val, Natalia, de Val Alda, Natalia, Wilson, Richard, Sundling, Christopher, Li, Yuxing, Stanfield, Robyn L, Wilson, Ian A, Ward, Andrew B, Karlsson Hedestam, Gunilla B, Wyatt, Richard T
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Vaccines - biosynthesis AIDS Vaccines - immunology alanine Animals antibodies Antibodies, Monoclonal - biosynthesis Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Antibodies, Neutralizing - biosynthesis Antibodies, Neutralizing - chemistry Antibodies, Neutralizing - immunology Binding sites Binding Sites - genetics Biological Sciences CD4 Antigens - genetics CD4 Antigens - metabolism Crystallization Drug Design ducks env Gene Products, Human Immunodeficiency Virus - genetics epitopes Glycoproteins HIV HIV-1 - immunology Human immunodeficiency virus Human immunodeficiency virus 1 Humans Immunization Immunoglobulin Fab Fragments - genetics Immunoglobulin Fab Fragments - metabolism Macaca mulatta Macaca mulatta - immunology Microscopy, Interference Models, Molecular Monkeys & apes neutralization Neutralization Tests PNAS Plus Primates Protein Conformation vaccination Vaccines
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